The deer mouse (Peromyscus maniculatus) and co-generic species are among the most abundant, species, and widely distributed North American mammals. Ranging from Alaska to Central America and occurring in many natural habitats they are frequently used as models to study the fundamental processes underlying adaptive physiology and behavior and are also used to monitor environmental toxicology. They directly affect many aspects of human health in the United States as reservoirs for infectious disease organisms. Established in 1985, the PGSC provides a reliable source of these animals and related materials to the national scientific and educational communities. The Stock Center proposes to continue providing peromyscines for biomedical and related research, to promote the species and its advantages, and to improve the usefulness of Peromyscus as a laboratory model.
One aim i s the development of cryopreservation technology for Peromyscus germinal material, thereby enabling economical preservation of mutant stocks. Another aim in the next several years is the development of a Peromyscus genetic map composed of polymerase chain reaction (PCR) based markers. A benefit of the nearly completed human and laboratory mouse genome projects is the ready application of that information to non-traditional species such as Peromyscus. In Peromyscus there are numerous questions of interest to biomedical and basic researchers for which genomic approaches would likely be worthwhile.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40RR014279-06
Application #
6771213
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Rall, William F
Project Start
1999-07-01
Project End
2006-03-31
Budget Start
2004-07-01
Budget End
2006-03-31
Support Year
6
Fiscal Year
2004
Total Cost
$180,625
Indirect Cost
Name
University of South Carolina at Columbia
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
111310249
City
Columbia
State
SC
Country
United States
Zip Code
29208
Wiedmeyer, Charles E; Crossland, Janet P; Veres, Monika et al. (2014) Hematologic and serum biochemical values of 4 species of Peromyscus mice and their hybrids. J Am Assoc Lab Anim Sci 53:336-43
Jasarevic, Eldin; Bailey, Drew H; Crossland, Janet P et al. (2013) Evolution of monogamy, paternal investment, and female life history in Peromyscus. J Comp Psychol 127:91-102
Veres, Monika; Duselis, Amanda R; Graft, Audrey et al. (2012) The biology and methodology of assisted reproduction in deer mice (Peromyscus maniculatus). Theriogenology 77:311-9
Yang, Geer; Veres, Monika; Szalai, Gabor et al. (2011) Biotransport phenomena in freezing mammalian oocytes. Ann Biomed Eng 39:580-91
Mlynarski, Elisabeth E; Obergfell, Craig; Dewey, Michael J et al. (2010) A unique late-replicating XY to autosome translocation in Peromyscus melanophrys. Chromosome Res 18:179-89
Weber, Jesse N; Peters, Maureen B; Tsyusko, Olga V et al. (2010) Five Hundred Microsatellite Loci for Peromyscus. Conserv Genet 11:1243-1246
Duselis, Amanda R; Vrana, Paul B (2010) Aberrant growth and pattern formation in Peromyscus hybrid placental development. Biol Reprod 83:988-96
Mlynarski, E E; Obergfell, C J; O'Neill, M J et al. (2010) Divergent patterns of breakpoint reuse in Muroid rodents. Mamm Genome 21:77-87
Ramsdell, Clifton M; Lewandowski, Adrienne A; Glenn, Julie L Weston et al. (2008) Comparative genome mapping of the deer mouse (Peromyscus maniculatus) reveals greater similarity to rat (Rattus norvegicus) than to the lab mouse (Mus musculus). BMC Evol Biol 8:65
Glenn, Julie L Weston; Chen, Chin-Fu; Lewandowski, Adrienne et al. (2008) Expressed sequence tags from Peromyscus testis and placenta tissue: analysis, annotation, and utility for mapping. BMC Genomics 9:300

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