This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS DESCRIPTION (provided by applicant): The deer mouse (Peromyscus maniculatus) and co-generic species are among the most abundant, species, and widely distributed North American mammals. Ranging from Alaska to Central America and occurring in many natural habitats they are frequently used as models to study the fundamental processes underlying adaptive physiology and behavior and are also used to monitor environmental toxicology. They directly affect many aspects of human health in the United States as reservoirs for infectious disease organisms. Established in 1985, the PGSC provides a reliable source of these animals and related materials to the national scientific and educational communities. The Stock Center proposes to continue providing peromyscines for biomedical and related research, to promote the species and its advantages, and to improve the usefulness of Peromyscus as a laboratory model.
One aim i s the development of cryopreservation technology for Peromyscus germinal material, thereby enabling economical preservation of mutant stocks. Another aim in the next several years is the development of a Peromyscus genetic map composed of polymerase chain reaction (PCR) based markers. A benefit of the nearly completed human and laboratory mouse genome projects is the ready application of that information to non-traditional species such as Peromyscus. In Peromyscus there are numerous questions of interest to biomedical and basic researchers for which genomic approaches would likely be worthwhile.
|Wiedmeyer, Charles E; Crossland, Janet P; Veres, Monika et al. (2014) Hematologic and serum biochemical values of 4 species of Peromyscus mice and their hybrids. J Am Assoc Lab Anim Sci 53:336-43|
|Jasarevic, Eldin; Bailey, Drew H; Crossland, Janet P et al. (2013) Evolution of monogamy, paternal investment, and female life history in Peromyscus. J Comp Psychol 127:91-102|
|Veres, Monika; Duselis, Amanda R; Graft, Audrey et al. (2012) The biology and methodology of assisted reproduction in deer mice (Peromyscus maniculatus). Theriogenology 77:311-9|
|Yang, Geer; Veres, Monika; Szalai, Gabor et al. (2011) Biotransport phenomena in freezing mammalian oocytes. Ann Biomed Eng 39:580-91|
|Mlynarski, Elisabeth E; Obergfell, Craig; Dewey, Michael J et al. (2010) A unique late-replicating XY to autosome translocation in Peromyscus melanophrys. Chromosome Res 18:179-89|
|Weber, Jesse N; Peters, Maureen B; Tsyusko, Olga V et al. (2010) Five Hundred Microsatellite Loci for Peromyscus. Conserv Genet 11:1243-1246|
|Duselis, Amanda R; Vrana, Paul B (2010) Aberrant growth and pattern formation in Peromyscus hybrid placental development. Biol Reprod 83:988-96|
|Mlynarski, E E; Obergfell, C J; O'Neill, M J et al. (2010) Divergent patterns of breakpoint reuse in Muroid rodents. Mamm Genome 21:77-87|
|Glenn, Julie L Weston; Chen, Chin-Fu; Lewandowski, Adrienne et al. (2008) Expressed sequence tags from Peromyscus testis and placenta tissue: analysis, annotation, and utility for mapping. BMC Genomics 9:300|
|Mlynarski, E E; Obergfell, C J; Rens, W et al. (2008) Peromyscus maniculatus--Mus musculus chromosome homology map derived from reciprocal cross species chromosome painting. Cytogenet Genome Res 121:288-92|
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