Abstract

Significance: Proteases make up 2% of the human proteome (3), and their functional activity is a unique, irreversible post-translational modification of their target substrates (7). Proteases are involved in a number of important physiological functions from blood coagulation to digestion and pathophysiological activities necessary for activation and propagation of cancer cascades and Alzheimer's disease (8). More information about protease biology and pathophysiology in addition to new selective therapeutics would be important for understanding and treating human disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Biotechnology Resource Grants (P41)
Project #
1P41CA196276-01
Application #
8702411
Study Section
Special Emphasis Panel (ZRG1-IMM-N (41))
Project Start
2014-09-24
Project End
2019-08-31
Budget Start
2014-09-24
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$342,556
Indirect Cost
$122,556

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Cormier, Anthony; Campbell, Melody G; Ito, Saburo et al. (2018) Cryo-EM structure of the ?v?8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol 25:698-704
Debela, Mekdes; Magdolen, Viktor; Skala, Wolfgang et al. (2018) Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Sci Rep 8:10705
Takasaka, Naoki; Seed, Robert I; Cormier, Anthony et al. (2018) Integrin ?v?8-expressing tumor cells evade host immunity by regulating TGF-? activation in immune cells. JCI Insight 3:
Li, Xiuyuan; Sevillano, Natalia; La Greca, Florencia et al. (2018) Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. J Am Chem Soc 140:6518-6521
Pollock, Samuel B; Hu, Amy; Mou, Yun et al. (2018) Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proc Natl Acad Sci U S A 115:2836-2841
Truillet, Charles; Oh, Hsueh Ling J; Yeo, Siok Ping et al. (2018) Imaging PD-L1 Expression with ImmunoPET. Bioconjug Chem 29:96-103
Zhou, Yu; Zou, Hao; Yau, Christina et al. (2018) Discovery of internalizing antibodies to basal breast cancer cells. Protein Eng Des Sel 31:17-28
Acker, Timothy M; Gable, Jonathan E; Bohn, Markus-Frederik et al. (2017) Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases. J Am Chem Soc 139:11650-11653
Kara, Emrah; Manna, Dipankar; Løset, Geir Åge et al. (2017) Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thromb Haemost 117:1750-1760
Roncase, Emily J; Moon, Clara; Chatterjee, Sandip et al. (2017) Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria. ACS Chem Biol 12:1556-1565

Showing the most recent 10 out of 25 publications