The P41 Tissue Engineering Resource Center (TERC) has established innovative biomaterials, bioreactors, and tissue engineering models since its inception in August 2004. The core themes for TERC continue to evolve along with the scientific and technological progress. Initially the focus was on functional tissue engineering achieved through the integration of the key elements in the field via a systems approach - cells, scaffolds and bioreactors. This renewal continues this path, with an expanded impact for the Center themes in areas of clinical relevance, disease models, and research tools applicable to biological inquiry. In the renewal plans, we maintain a focus in two critical areas: (a) skeletal systems and (b) cardiovascular systems, while progressing toward new impact for the underlying fundamentals and translational strategies. The common aspects for both areas (skeletal tissues, cardiovascular systems) include: cell sources, genetic tools, imaging (molecular, cellular, tissue levels), biomechanics (from cells to tissues), modeling (computational biology, transport, electrical and mechanical signal transduction) and the use of animal models, with strong focus on advancing biological research and translation into medical applications. The Center will continue to be led by two long-time collaborators, David Kaplan at Tufts University and Gordana Vunjak-Novakovic at Columbia University, who also head the two cores in the Center (biomaterials, bioreactors). A large group of faculty and collaborators will contribute the activities in the Center, and a stellar Scientific Advisory Board will continue to provide critical guidance to the Center. Public Health Relevance: The need for new ways to design, study and use human tissues continues to grow. Thus, the focus and importance of Center programs continues to expand, with impact in understanding disease, repairing clinical defects for tissue and organ needs, and to screen therapeutic treatments

Public Health Relevance

The need for new ways to design, study and use human tissues continues to grow. Thus, the focus and importance of Center programs continues to expand, with impact in understanding disease, repairing clinical defects for tissue and organ needs, and to screen therapeutic treatments

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
3P41EB002520-06A1S1
Application #
7899427
Study Section
Special Emphasis Panel (ZRG1-BST-Z (40))
Program Officer
Hunziker, Rosemarie
Project Start
2003-09-01
Project End
2011-07-31
Budget Start
2009-08-15
Budget End
2011-07-31
Support Year
6
Fiscal Year
2009
Total Cost
$153,147
Indirect Cost
Name
Tufts University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
073134835
City
Medford
State
MA
Country
United States
Zip Code
02155
Huang, Wenwen; Ling, Shengjie; Li, Chunmei et al. (2018) Silkworm silk-based materials and devices generated using bio-nanotechnology. Chem Soc Rev 47:6486-6504
Ronaldson-Bouchard, Kacey; Ma, Stephen P; Yeager, Keith et al. (2018) Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature 556:239-243
Marturano-Kruik, Alessandro; Nava, Michele Maria; Yeager, Keith et al. (2018) Human bone perivascular niche-on-a-chip for studying metastatic colonization. Proc Natl Acad Sci U S A 115:1256-1261
Algarrahi, Khalid; Affas, Saif; Sack, Bryan S et al. (2018) Repair of injured urethras with silk fibroin scaffolds in a rabbit model of onlay urethroplasty. J Surg Res 229:192-199
Algarrahi, Khalid; Franck, Debra; Savarino, Alyssa et al. (2018) Bilayer silk fibroin grafts support functional oesophageal repair in a rodent model of caustic injury. J Tissue Eng Regen Med 12:e1068-e1075
Chen, Timothy; Vunjak-Novakovic, Gordana (2018) In vitro Models of Ischemia-Reperfusion Injury. Regen Eng Transl Med 4:142-153
Wobma, Holly M; Tamargo, Manuel A; Goeta, Shahar et al. (2018) The influence of hypoxia and IFN-? on the proteome and metabolome of therapeutic mesenchymal stem cells. Biomaterials 167:226-234
Ling, Shengjie; Wang, Qi; Zhang, Dong et al. (2018) Integration of stiff graphene and tough silk for the design and fabrication of versatile electronic materials. Adv Funct Mater 28:
Dinjaski, Nina; Huang, Wenwen; Kaplan, David L (2018) Recursive Directional Ligation Approach for Cloning Recombinant Spider Silks. Methods Mol Biol 1777:181-192
Liu, Bohao; Lee, Benjamin W; Nakanishi, Koki et al. (2018) Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Nat Biomed Eng 2:293-303

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