Abstract

Hyperpolarized (HP) MRI using Dynamic Nuclear Polarization (DNP) is a powerful new imaging technique that uses specialized instrumentation to provide MR signal enhancement of 10,000-100,000 fold for [13]C labeled compounds. To advance current hyperpolarized carbon-13 methodology, major advances in Dynamic Nuclear Polarization (DNP) instrumentation/methods and MR acquisition techniques are required to increase the applicability, reliability and information content of this emerging imaging technology. In conjunction with the Collaborative Project investigators and driven by the needs of their research projects, this Technology Research and Development (TR&D1) project is designed to: 1) develop and test new DNP polarizer hardware and techniques to produce higher, more robust liquid state polarizations (benefits all projects), 2) enable reliable multi-compound polarizations (with TR&D2, CP1-2, 3-7), and 3) develop robust MR acquisition techniques tailored to specific anatomic location, animal model, hyperpolarized molecule(s) and approach for all Collaborative Projects. The methods developed will also be disseminated to the Service Project investigators and to the broader HP research community via web documents and downloads. This TR&D1 project will be carried out by a multidisciplinary team with extensive expertise in basic NMR science, mechanical, electrical and instrumentation design, bioengineering, and DNP physics and engineering. In addition to this expertise, we have extensive facilities including mechanical and electronics shops, multiple NMR systems, MR scanners, and research DNP polarizers.

Public Health Relevance

This project aims to advance significantly the performance, applicability, scope and information content of hyperpolarized MRI through novel instrumentation and technique development. These enhancements are designed to greatly improve the quality and productivity ofthe Collaborative Projects investigating improved methods for the clinical management of a wide range of human diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
1P41EB013598-01
Application #
8188399
Study Section
Special Emphasis Panel (ZEB1-OSR-E (M2))
Project Start
Project End
Budget Start
2011-08-01
Budget End
2012-06-30
Support Year
1
Fiscal Year
2011
Total Cost
$630,146
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Autry, Adam W; Hashizume, Rintaro; James, C David et al. (2018) Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging. Contrast Media Mol Imaging 2018:3215658
Axler, Sheldon; Shin, Peter J (2018) THE NEUMANN PROBLEM ON ELLIPSOIDS. J Appl Math Comput 57:261-278
von Morze, Cornelius; Merritt, Matthew E (2018) Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology. NMR Biomed :e3937
Truillet, Charles; Parker, Matthew F L; Huynh, Loc T et al. (2018) Measuring glucocorticoid receptor expression in vivo with PET. Oncotarget 9:20399-20408
Li, Nan; Liu, Shengping; Hu, Xiaoqing et al. (2018) Electromagnetic Field and Radio Frequency Circuit Co-Simulation for Magnetic Resonance Imaging Dual-Tuned Radio Frequency Coils. IEEE Trans Magn 54:
Sriram, Renuka; Sun, Jinny; Villanueva-Meyer, Javier et al. (2018) Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate. ACS Infect Dis 4:797-805
Morze, Cornelius von; Allu, Prasanna K R; Chang, Gene Y et al. (2018) Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo. Sci Rep 8:2088
Zhu, Xucheng; Gordon, Jeremy W; Bok, Robert A et al. (2018) Dynamic diffusion-weighted hyperpolarized 13 C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport. Magn Reson Med :
Larson, Peder E Z; Chen, Hsin-Yu; Gordon, Jeremy W et al. (2018) Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients. NMR Biomed 31:e3997
Chen, Hsin-Yu; Larson, Peder E Z; Gordon, Jeremy W et al. (2018) Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer. Magn Reson Med 80:2062-2072

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