The Laser Microbeam and Medical Program (LAMMP) is a NIH Biomedical Technology Resource Center dedicated to the use of lasers and optics in biology and medicine. LAMMP is located within the Beckman Laser Institute (BLI), an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. Overall resource objectives are to promote a well-balanced Center with activities in technological research and development, collaborative research, service, training, and dissemination. In this sixth renewal application of LAMMP, we continue to emphasize our unique capabilities to facilitate """"""""translational"""""""" research by rapidly moving basic science and technology discoveries from """"""""blackboard to benchtop to bedside"""""""". This is accomplished by combining state of the art optical technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinical care. LAMMP provides both Microscopy and Microbeam Technologies (MMT) for high-resolution functional imaging and manipulation of living cells and tissues and Medical Translational Technologies (MTT) for non- and minimally-invasive monitoring, treating, and imaging pre-clinical animal models and human subjects. In addition, we propose to establish a new core, Virtual Photonics Technologies (VPT) for developing computational models and methods that advance the performance of biophotonic technologies, and enhance the information content derived from optical measurements. Seven Technology Research and Development projects are proposed that will result in the fabrication of several new instruments as well as the creation of multi-functional software. These projects build on our longstanding expertise in light-tissue interaction models and Biophotonics technologies, including laser microbeams, non-linear microscopy, optical coherence tomography, spatial/temporal modulation methods, and diffuse optics. LAMMP cores contain complementary technologies that are capable of quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Collaborative studies are proposed that advance these technologies so they become widely-available, enabling methods in Biology and Medicine. Throughout the grant we emphasize the relevance of LAMMP technologies to Medicine in areas such as cancer, cardiovascular disease, metabolic syndrome, and neurologic function, as well as fundamental biological process, such as mechano-transduction, wound repair, angiogenesis, fibrosis, and cell death.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZRG1-SBIB-L (40))
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Conroy, Richard
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University of California Irvine
Schools of Medicine
United States
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Hirschberg, Henry; Berg, Kristian; Peng, Qian (2018) Photodynamic therapy mediated immune therapy of brain tumors. Neuroimmunol Neuroinflamm 5:
Ghijsen, Michael; Lentsch, Griffin R; Gioux, Sylvain et al. (2018) Quantitative real-time optical imaging of the tissue metabolic rate of oxygen consumption. J Biomed Opt 23:1-12
Shin, Diane; Christie, Catherine; Ju, David et al. (2018) Photochemical internalization enhanced macrophage delivered chemotherapy. Photodiagnosis Photodyn Ther 21:156-162
Madsen, Steen J; Christie, Catherine; Huynh, Khoi et al. (2018) Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: an in vivo histological study in rats. J Biomed Opt 23:1-7
Lentsch, Griffin; Balu, Mihaela; Williams, Joshua et al. (2018) In vivo multiphoton microscopy of melasma. Pigment Cell Melanoma Res :
Moon, Sucbei; Chen, Zhongping (2018) Phase-stability optimization of swept-source optical coherence tomography. Biomed Opt Express 9:5280-5295
Lertsakdadet, Ben; Yang, Bruce Y; Dunn, Cody E et al. (2018) Correcting for motion artifact in handheld laser speckle images. J Biomed Opt 23:1-7
Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883
Li, Yan; Chen, Zhongping (2018) Multimodal Intravascular Photoacoustic and Ultrasound Imaging. Biomed Eng Lett 8:193-201
Ponticorvo, Adrien; Rowland, Rebecca; Baldado, Melissa et al. (2018) Evaluating clinical observation versus Spatial Frequency Domain Imaging (SFDI), Laser Speckle Imaging (LSI) and thermal imaging for the assessment of burn depth. Burns :

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