Abstract

In the MMT core, focused laser beams are used to achieve high-resolution imaging and to perform precisely controlled micro-manipulations of biological tissues in situ and in vivo. This core includes confocal and nonlinear optical microscopy technologies, optical tweezers and advanced micro-beam techniques. During previous LAMMP funding cycles, the MMT core has made many pivotal contributions to the field of laser-based microscopy, and has broken new ground in applying these technologies to relevant biomedical problems. In the current LAMMP renewal, we continue to push laser microscopy techniques for addressing pertinent questions in cell and tissue biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015890-38
Application #
9480311
Study Section
Special Emphasis Panel (ZEB1-OSR-C (J1)P)
Program Officer
Shabestari, Behrouz
Project Start
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
38
Fiscal Year
2017
Total Cost
$149,391
Indirect Cost
$52,698

  Institution

Name
University of California Irvine
Department
Type
Domestic Higher Education
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617

  Publications

Qu, Yueqiao; He, Youmin; Saidi, Arya et al. (2018) In Vivo Elasticity Mapping of Posterior Ocular Layers Using Acoustic Radiation Force Optical Coherence Elastography. Invest Ophthalmol Vis Sci 59:455-461
Cochran, Jeffrey M; Busch, David R; Leproux, Anaïs et al. (2018) Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment. J Biomed Opt 24:1-11
Ghijsen, Michael; Rice, Tyler B; Yang, Bruce et al. (2018) Wearable speckle plethysmography (SPG) for characterizing microvascular flow and resistance. Biomed Opt Express 9:3937-3952
Nair, Rohit Kumar; Christie, Catherine; Ju, David et al. (2018) Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI). Lasers Med Sci 33:1747-1755
Moon, Sucbei; Qu, Yueqiao; Chen, Zhongping (2018) Characterization of spectral-domain OCT with autocorrelation interference response for axial resolution performance. Opt Express 26:7253-7269
Miao, Yusi; Jing, Joseph C; Desai, Vineet et al. (2018) Automated 3D segmentation of methyl isocyanate-exposed rat trachea using an ultra-thin, fully fiber optic optical coherence endoscopic probe. Sci Rep 8:8713
Lam, Jesse H; O'Sullivan, Thomas D; Park, Tim S et al. (2018) Non-invasive Dual-Channel Broadband Diffuse Optical Spectroscopy of Massive Hemorrhage and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in Swine. Mil Med 183:150-156
White, Sean M; Valdebran, Manuel; Kelly, Kristen M et al. (2018) Simultaneous Blood Flow Measurement and Dermoscopy of Skin Lesions Using Dual-Mode Dermascope. Sci Rep 8:16941
Hirschberg, Henry; Berg, Kristian; Peng, Qian (2018) Photodynamic therapy mediated immune therapy of brain tumors. Neuroimmunol Neuroinflamm 5:
Ghijsen, Michael; Lentsch, Griffin R; Gioux, Sylvain et al. (2018) Quantitative real-time optical imaging of the tissue metabolic rate of oxygen consumption. J Biomed Opt 23:1-12

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