TRD 2 TRD project 2 will develop novel optical coherence tomography (OCT) technologies to address unmet needs in the functional imaging of tissue.
Specific Aim #1 addresses the need for high-speed and high- resolution angiographic imaging systems for preclinical research. A new high-speed optical architecture for high-resolution optical coherence microscopy (OCM) will be constructed that is 100 times faster than existing OCM instrumentation. These improvements in speed will be leveraged to expand high resolution angiography and quantitative flow imaging to wider imaging fields, and to improve the temporal resolution of these measurements.
Specific Aim #2 builds upon the recent development of long depth range, high-speed OCT architectures to create an intraoperative OCT camera platform. Vectorial birefringence imaging through polarization-sensitive OCT will be incorporated into the camera system to allow imagining of optical birefringence across a surgical field. While this platform technology can have application in numerous surgical procedures, it will be specifically validated as a means for functional imaging of peripheral nerve injuries. Finally, specific aim #3 addresses the need for improved tools to study lung function in small animal models of chronic inflammatory disease and cystic fibrosis (CF). To study the consequences of inflammation-driven lymphatic remodeling on lung function, catheters and methods to image the collecting lymphatics of the mouse trachea will be developed and validated. Using similar catheters and a new set of imaging methods, an in vivo platform providing measurements of airway surface liquid properties and mucociliary transport in ferret models of CF will be demonstrated. Through these aims, TRD project 2 will develop, validate, and deliver innovative new OCT technologies to our collaborating project investigators and to the broader research community.
TRD 2 Imaging technologies that expand our understanding of tissue function in health and disease are essential to the development and evaluation of new therapies. To overcome the limitations of existing tools, this work will develop responsive and innovative technologies for imaging tissue perfusion in cancer, peripheral nerve health in traumatic injuries, and lung function in chronic inflammatory diseases and cystic fibrosis.
| Inoue, Yoshitaka; Liu, Yuk Ming; Otawara, Masayuki et al. (2018) Resolvin D2 Limits Secondary Tissue Necrosis After Burn Wounds in Rats. J Burn Care Res 39:423-432 |
| Villiger, Martin; Otsuka, Kenichiro; Karanasos, Antonios et al. (2018) Repeatability Assessment of Intravascular Polarimetry in Patients. IEEE Trans Med Imaging 37:1618-1625 |
| Jones, Dennis; Meijer, Eelco F J; Blatter, Cedric et al. (2018) Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Sci Transl Med 10: |
| Bouta, Echoe M; Blatter, Cedric; Ruggieri, Thomas A et al. (2018) Lymphatic function measurements influenced by contrast agent volume and body position. JCI Insight 3: |
| Siddiqui, Meena; Nam, Ahhyun S; Tozburun, Serhat et al. (2018) High-speed optical coherence tomography by circular interferometric ranging. Nat Photonics 12:111-116 |
| Tozburun, Serhat; Blatter, Cedric; Siddiqui, Meena et al. (2018) Phase-stable Doppler OCT at 19 MHz using a stretched-pulse mode-locked laser. Biomed Opt Express 9:952-961 |
| Blatter, Cedric; Meijer, Eelco F J; Padera, Timothy P et al. (2018) Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography. J Biophotonics 11:e201700017 |
| Bourquard, Aurélien; Pablo-Trinidad, Alberto; Butterworth, Ian et al. (2018) Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation. Sci Rep 8:5301 |
| Nam, Ahhyun S; Easow, Jeena M; Chico-Calero, Isabel et al. (2018) Wide-Field Functional Microscopy of Peripheral Nerve Injury and Regeneration. Sci Rep 8:14004 |
| Cuartas-Vélez, Carlos; Restrepo, René; Bouma, Brett E et al. (2018) Volumetric non-local-means based speckle reduction for optical coherence tomography. Biomed Opt Express 9:3354-3372 |
Showing the most recent 10 out of 134 publications
