TR&D 2. Quantitative multi-contrast MRI at 3T and 7T. Principal investigators: Peter C.M. van Zijl, Professor of Radiology Hanzhang Lu, Associate Professor of Radiology SUMMARY The discovery of tissue biomarkers that can provide early and more specific information regarding physiological or metabolic changes can be seen as the holy grail of clinical imaging. The availability of such biomarkers is one of the main issues that we are continuously being inquired about by our collaborative projects (CPs), which study such topics as autism spectum disorder (ASD), pediatric brain development, Attention Deficit Hyperactivity Disorder (ADHD), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Huntington's Disease (HD), Schizophrenia (SCZ), and brain tumors. Our overall goal is therefore to develop MRI methodologies at 3T and 7T that can provide the quantitative biomarkers needed by our CPs. Towards this goal, AIM 1 is focused on the development of exchange transfer imaging (ETI) of the brain. Based originally on chemical exchange saturation transfer (CEST) MRI, which uses pulse sequences similar to conventional magnetization transfer MRI, ETI is broader as it allows the assessment of tissue metabolites that contain exchangeable protons using not only radiofrequency saturation, but instead pulsed excitation sequences that can be used to edit out specific tissue components based on their exchange rate or transverse relaxation time. In addition, we will exploit multi-transmit capabilities of the scanner to avoid amplifier duty cycle limitations on the human scanners.
In AIM 2, we will develop methods to determine quantitative magnetic susceptibilities of tissue independent of the orientation of the brain. The purpose of Aim 3 is to design technology that allows assessment of both relative (changes in) and absolute arterial and arteriolar cerebral blood volume (CBVa), venous cerebral blood volume (CBVv), and cerebral metabolic rate of oxygen metabolism (CMRO2).

Public Health Relevance

We are developing MRI biomarkers that can provide early and more specific information regarding physiological or metabolic changes in brain tissue before such changes would be visible in standard clinical images. The suitability of these biomarkers will be tested through collaboration with research and clinical experts on autism spectum disorder (ASD), pediatric brain development, Attention Deficit Hyperactivity Disorder (ADHD), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Huntington's Disease (HD), Schizophrenia (SCZ), and brain tumors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015909-20
Application #
9997694
Study Section
Special Emphasis Panel (ZEB1)
Project Start
2000-07-01
Project End
2021-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
20
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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Aggarwal, Manisha; Li, Xu; Gröhn, Olli et al. (2018) Nuclei-specific deposits of iron and calcium in the rat thalamus after status epilepticus revealed with quantitative susceptibility mapping (QSM). J Magn Reson Imaging 47:554-564
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Hua, Jun; Blair, Nicholas I S; Paez, Adrian et al. (2018) Altered functional connectivity between sub-regions in the thalamus and cortex in schizophrenia patients measured by resting state BOLD fMRI at 7T. Schizophr Res :
Knutsson, Linda; Xu, Jiadi; Ahlgren, André et al. (2018) CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena. Magn Reson Med 80:1320-1340
Hermans, Lize; Leunissen, Inge; Pauwels, Lisa et al. (2018) Brain GABA Levels Are Associated with Inhibitory Control Deficits in Older Adults. J Neurosci 38:7844-7851
Kamil, Rebecca J; Jacob, Athira; Ratnanather, John Tilak et al. (2018) Vestibular Function and Hippocampal Volume in the Baltimore Longitudinal Study of Aging (BLSA). Otol Neurotol 39:765-771
Liu, Peiying; De Vis, Jill B; Lu, Hanzhang (2018) Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review. Neuroimage :
Hua, Jun; Liu, Peiying; Kim, Tae et al. (2018) MRI techniques to measure arterial and venous cerebral blood volume. Neuroimage :
Li, Yang; Mao, Deng; Li, Zhiqiang et al. (2018) Cardiac-triggered pseudo-continuous arterial-spin-labeling: A cost-effective scheme to further enhance the reliability of arterial-spin-labeling MRI. Magn Reson Med 80:969-975

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