Technology Research and Development Project #1 Towards Rapid Continuous Comprehensive MR Imaging: New Methods, New Paradigms, and New Applications TR&D #1 Principal Investigators: Ricardo Otazo, PhD and Daniel K. Sodickson, MD, PhD The broad mission of our Center for Advanced Imaging Innovation and Research (CAI2R) is to bring together collaborative translational research teams for the development of high-impact biomedical imaging technologies, with the ultimate goal of changing day-to-day clinical practice. Technology Research and Development (TR&D) project #1 aims at a new use of time in imaging, deploying leading-edge methods of rapid image acquisition and advanced image reconstruction to replace traditional complex, targeted, and inefficient imaging protocols with simple, comprehensive, volumetric acquisitions that contain rich information about multiple complementary contrasts and diverse dynamics.
Specific aims are as follows: (1) New methods: Develop novel rapid MR acquisition and reconstruction strategies specifically tailored to the needs of collaborative and service projects, taking advantage of compressed sensing, parallel imaging and model-based reconstruction. (2) New paradigm: Establish a new paradigm for MR scanning, using continuously-updated motion-robust comprehensive acquisitions eliminating dead time, coupled with tailored image reconstructions with user- defined contrast and spatiotemporal profiles. (3) New applications: Implement this new scanning paradigm in collaborative and service projects and evaluate its efficacy in routine patient populations for high-volume high-impact clinical applications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB017183-04
Application #
9319760
Study Section
Special Emphasis Panel (ZEB1)
Project Start
Project End
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
4
Fiscal Year
2017
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10010
Zibetti, Marcelo V W; Sharafi, Azadeh; Otazo, Ricardo et al. (2018) Accelerating 3D-T1? mapping of cartilage using compressed sensing with different sparse and low rank models. Magn Reson Med 80:1475-1491
Vaidya, Manushka V; Sodickson, Daniel K; Collins, Christopher M et al. (2018) Disentangling the effects of high permittivity materials on signal optimization and sample noise reduction via ideal current patterns. Magn Reson Med :
Schramm, Georg; Holler, Martin; Rezaei, Ahmadreza et al. (2018) Evaluation of Parallel Level Sets and Bowsher's Method as Segmentation-Free Anatomical Priors for Time-of-Flight PET Reconstruction. IEEE Trans Med Imaging 37:590-603
Chawla, Sanjeev; Kister, Ilya; Sinnecker, Tim et al. (2018) Longitudinal study of multiple sclerosis lesions using ultra-high field (7T) multiparametric MR imaging. PLoS One 13:e0202918
Yu, Zidan; Zhao, Tiejun; Assländer, Jakob et al. (2018) Exploring the sensitivity of magnetic resonance fingerprinting to motion. Magn Reson Imaging 54:241-248
Yoon, Jeong Hee; Lee, Jeong Min; Yu, Mi Hye et al. (2018) Evaluation of Transient Motion During Gadoxetic Acid-Enhanced Multiphasic Liver Magnetic Resonance Imaging Using Free-Breathing Golden-Angle Radial Sparse Parallel Magnetic Resonance Imaging. Invest Radiol 53:52-61
Fieremans, Els; Lee, Hong-Hsi (2018) Physical and numerical phantoms for the validation of brain microstructural MRI: A cookbook. Neuroimage 182:39-61
Burke, Christopher J; Kaplan, Daniel; Block, Tobias et al. (2018) Clinical Utility of Continuous Radial Magnetic Resonance Imaging Acquisition at 3 T in Real-time Patellofemoral Kinematic Assessment: A Feasibility Study. Arthroscopy 34:726-733
Ianniello, Carlotta; de Zwart, Jacco A; Duan, Qi et al. (2018) Synthesized tissue-equivalent dielectric phantoms using salt and polyvinylpyrrolidone solutions. Magn Reson Med 80:413-419
Benkert, Thomas; Mugler 3rd, John P; Rigie, David S et al. (2018) Hybrid T2 - and T1 -weighted radial acquisition for free-breathing abdominal examination. Magn Reson Med 80:1935-1948

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