for the Center for Molecular Imaging Technology and Translation The Center for Molecular Imaging Technology and Translation (CMITT) will be a national resource located within the newly created Gordon Center for Medical Imaging (GCMI) at the Massachusetts General Hospital. Working within the interdisciplinary environment (e.g., imaging sciences; image reconstruction and processing; pharmacokinetics) of the Gordon Center, the aim of CMITT is to develop, validate and disseminate cutting-edge imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous acquisition of PET and MR. CMITT consists of three Technology Research and Development projects (TR&Ds): TR&D1 aims at breaking down the resolution barrier in PET. By developing enabling technologies for attenuation and motion field estimation as well as PSH modeling we can achieve the intrinsic resolution of PET, about 4mm, in the breathing patient by using novel accelerated MR acquisitions with sparse sampling. TR&D2 will develop the unified statistical model of joint reconstruction of PET and MR that incorporates the corrections developed in TR&D1. TR&D3 will develop the pharmacokinetic modeling of physiological processes in simultaneous PET/MR (TR&D3) in quantitative PET/MR images that enable exploration of molecular physiology. There is currently no PET-focused Biomedical Technology Resource Center supported by NIBIB. Thus CMITT seeks to fill a clear national need for PET/MR imaging technology development, one that is agnostic with respect to commercial platform and, in many instances, applies equally to PET or MR alone. The Resource provides a unique environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging scientists throughout the country as well as Europe, Asia and Australia. CMITT will provide extensive training opportunities for students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of normal function and disease through active dissemination of new knowledge and technology.

Public Health Relevance

for the Center for Molecular Imaging Technology and Translation (CMITT) The Center for Molecular Imaging Technology and Translation (CMITT) will be a national resource located at the Massachusetts General Hospital dedicated to promoting biomedical imaging technology development. Working within the interdisciplinary environment (e.g., imaging sciences; image reconstruction and processing; pharmacokinetics), the aim of this Resource is to develop, validate and disseminate cutting-edge imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous acquisition of PET and MR to yield more accurate diagnosis, characterization and follow up of cardiac, brain and cancer diseases in their very early stages. There is currently no PET-focused Biomedical Technology Resource Center supported by NIBIB. CMITT will fill a clear national need for PET/MR imaging technology development that is agnostic with respect to commercial platform and, in many instances, applicable to PET or MR alone. The Resource provides a unique environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging scientists throughout the country as well as Europe, Asia and Australia. CMITT will provide extensive training opportunities for students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of normal function and disease through active dissemination of new knowledge and technology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
1P41EB022544-01A1
Application #
9369479
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Atanasijevic, Tatjana
Project Start
2017-09-30
Project End
2022-06-30
Budget Start
2017-09-30
Budget End
2018-06-30
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
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