Abstract

The overall goals of the Collaboration and Service Core (C&S) are to provide non-specialists with access to MS technologies, software, methods, technical expertise and support developed in the Washington University (WU) Biomedical Mass Spectrometry (MS) Resource, and to provide experienced investigators with shared access to MS instrumentation and software so they can independently conduct sample analyses. Requests for C&S projects are evaluated by the Operational Team and selected based on established criteria. Completed, ongoing, and new C&S projects are evaluated for impact based on publications/productivity; tracked to document efficient MS instrument utilization; and monitored to insure that MS Resources are shared equitably with WU and outside users who acknowledge the contributions of the WU Biomedical MS Resource and comply with NIH public access policies.

Public Health Relevance

-Public Health Relevance. The Washington University Biomedical Mass Spectrometry Resource has a longstanding history as an active and productive citizen in the NIH Biotechnology Research Resources community. We propose to extend our mission by advancing mass spectrometry technology, development, and research, applying these discoveries to answer critical biomedical research questions, and training the next generation of researchers, towards the ultimate goal of improving public health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM103422-40
Application #
9199439
Study Section
Special Emphasis Panel (ZRG1-IMST-B)
Project Start
Project End
Budget Start
2017-01-01
Budget End
2017-12-31
Support Year
40
Fiscal Year
2017
Total Cost
$86,365
Indirect Cost
$29,732

  Institution

Name
Washington University
Department
Type
Domestic Higher Education
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Lu, Yue; Goodson, Carrie; Blankenship, Robert E et al. (2018) Primary and Higher Order Structure of the Reaction Center from the Purple Phototrophic Bacterium Blastochloris viridis: A Test for Native Mass Spectrometry. J Proteome Res 17:1615-1623
Fernandez, Estefania; Kose, Nurgun; Edeling, Melissa A et al. (2018) Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus. MBio 9:
Johnson, Britney; VanBlargan, Laura A; Xu, Wei et al. (2018) Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity 48:487-499.e5
Girard, T J; Grunz, K; Lasky, N M et al. (2018) Re-evaluation of mouse tissue factor pathway inhibitor and comparison of mouse and human tissue factor pathway inhibitor physiology. J Thromb Haemost 16:2246-2257
Hsu, Fong-Fu (2018) Mass spectrometry-based shotgun lipidomics - a critical review from the technical point of view. Anal Bioanal Chem 410:6387-6409
Hung, Putzer J; Johnson, Britney; Chen, Bo-Ruei et al. (2018) MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell 71:332-342.e8
Illes-Toth, Eva; Rempel, Don L; Gross, Michael L (2018) Pulsed Hydrogen-Deuterium Exchange Illuminates the Aggregation Kinetics of ?-Synuclein, the Causative Agent for Parkinson's Disease. ACS Chem Neurosci 9:1469-1476
Johnston, Adam B; Hilton, Denise M; McConnell, Patrick et al. (2018) A novel mode of capping protein-regulation by twinfilin. Elife 7:
Ikon, Nikita; Hsu, Fong-Fu; Shearer, Jennifer et al. (2018) Evaluation of cardiolipin nanodisks as lipid replacement therapy for Barth syndrome J Biomed Res 32:107-112
Schweitzer, George G; Collier, Sara L; Chen, Zhouji et al. (2018) Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. FASEB J :fj201800361R

Showing the most recent 10 out of 323 publications