Abstract

The overall goals of the Collaboration and Service Core (C&S) are to provide non-specialists with access to MS technologies, software, methods, technical expertise and support developed in the Washington University (WU) Biomedical Mass Spectrometry (MS) Resource, and to provide experienced investigators with shared access to MS instrumentation and software so they can independently conduct sample analyses. Requests for C&S projects are evaluated by the Operational Team and selected based on established criteria. Completed, ongoing, and new C&S projects are evaluated for impact based on publications/productivity; tracked to document efficient MS instrument utilization; and monitored to insure that MS Resources are shared equitably with WU and outside users who acknowledge the contributions of the WU Biomedical MS Resource and comply with NIH public access policies.

Public Health Relevance

-Public Health Relevance. The Washington University Biomedical Mass Spectrometry Resource has a longstanding history as an active and productive citizen in the NIH Biotechnology Research Resources community. We propose to extend our mission by advancing mass spectrometry technology, development, and research, applying these discoveries to answer critical biomedical research questions, and training the next generation of researchers, towards the ultimate goal of improving public health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM103422-41
Application #
9412486
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
41
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Shen, Guomin; Li, Shuang; Cui, Weidong et al. (2018) Membrane Protein Structure in Live Cells: Methodology for Studying Drug Interaction by Mass Spectrometry-Based Footprinting. Biochemistry 57:286-294
Mukherjee, Sumit; Xu, Wei; Hsu, Fong-Fu et al. (2018) Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major. Mol Microbiol :
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 97:1284-1298.e7
Rocha, Agostinho G; Franco, Antonietta; Krezel, Andrzej M et al. (2018) MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science 360:336-341
Frankfater, Cheryl; Jiang, Xuntian; Hsu, Fong-Fu (2018) Characterization of Long-Chain Fatty Acid as N-(4-Aminomethylphenyl) Pyridinium Derivative by MALDI LIFT-TOF/TOF Mass Spectrometry. J Am Soc Mass Spectrom 29:1688-1699
Henson, William R; Hsu, Fong-Fu; Dantas, Gautam et al. (2018) Lipid metabolism of phenol-tolerant Rhodococcus opacus strains for lignin bioconversion. Biotechnol Biofuels 11:339
Lucey, Brendan P; Hicks, Terry J; McLeland, Jennifer S et al. (2018) Effect of sleep on overnight cerebrospinal fluid amyloid ? kinetics. Ann Neurol 83:197-204
Johnson, Britney; McConnell, Patrick; Kozlov, Alex G et al. (2018) Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange. Cell Rep 23:2795-2804
Shu, Longfei; Zhang, Bojie; Queller, David C et al. (2018) Burkholderia bacteria use chemotaxis to find social amoeba Dictyostelium discoideum hosts. ISME J 12:1977-1993
Zayed, Mohamed A; Hsu, Fong-Fu; Patterson, Bruce W et al. (2018) Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques. J Lipid Res 59:730-738

Showing the most recent 10 out of 323 publications