The overall goals of the Collaboration and Service Core (C&S) are to provide non-specialists with access to MS technologies, software, methods, technical expertise and support developed in the Washington University (WU) Biomedical Mass Spectrometry (MS) Resource, and to provide experienced investigators with shared access to MS instrumentation and software so they can independently conduct sample analyses. Requests for C&S projects are evaluated by the Operational Team and selected based on established criteria. Completed, ongoing, and new C&S projects are evaluated for impact based on publications/productivity; tracked to document efficient MS instrument utilization; and monitored to insure that MS Resources are shared equitably with WU and outside users who acknowledge the contributions of the WU Biomedical MS Resource and comply with NIH public access policies.

Public Health Relevance

-Public Health Relevance. The Washington University Biomedical Mass Spectrometry Resource has a longstanding history as an active and productive citizen in the NIH Biotechnology Research Resources community. We propose to extend our mission by advancing mass spectrometry technology, development, and research, applying these discoveries to answer critical biomedical research questions, and training the next generation of researchers, towards the ultimate goal of improving public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM103422-41
Application #
9412486
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
41
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Hsu, Fong-Fu (2018) Mass spectrometry-based shotgun lipidomics - a critical review from the technical point of view. Anal Bioanal Chem 410:6387-6409
Hung, Putzer J; Johnson, Britney; Chen, Bo-Ruei et al. (2018) MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell 71:332-342.e8
Illes-Toth, Eva; Rempel, Don L; Gross, Michael L (2018) Pulsed Hydrogen-Deuterium Exchange Illuminates the Aggregation Kinetics of ?-Synuclein, the Causative Agent for Parkinson's Disease. ACS Chem Neurosci 9:1469-1476
Johnston, Adam B; Hilton, Denise M; McConnell, Patrick et al. (2018) A novel mode of capping protein-regulation by twinfilin. Elife 7:
Ikon, Nikita; Hsu, Fong-Fu; Shearer, Jennifer et al. (2018) Evaluation of cardiolipin nanodisks as lipid replacement therapy for Barth syndrome J Biomed Res 32:107-112
Schweitzer, George G; Collier, Sara L; Chen, Zhouji et al. (2018) Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. FASEB J :fj201800361R
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Li, Ke Sherry; Shi, Liuqing; Gross, Michael L (2018) Mass Spectrometry-Based Fast Photochemical Oxidation of Proteins (FPOP) for Higher Order Structure Characterization. Acc Chem Res 51:736-744
Chanthamontri, C Ken; Jordan, David; Wang, Wenjie et al. (2018) Ebola Viral Protein 35 N-terminus is a Parallel Tetramer. Biochemistry :
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :

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