Maximizing the impact of each DBP project requires frequent communication so that we fully understand the nature of the biological problem being addressed and that the collaborating investigator(s) fully understand the capabilities of each available technology. We will continue to work actively with the investigators of each DBP to optimize and implement the most effective experimental design for each project. Our metric for successful completion of a DBP project is publication and we expect to fully engage in authoring each manuscript. As such, we will likewise actively work with each DBP collaborator to design, construct, and revise manuscripts that we will target for publication in top journals.
We aim for every DBP project to generate at least one publication. This strategy will also aid in disseminating the center technologies to new audiences, those of the collaborator's biomedical specialty field. As each DBP in our portfolio progresses, we will actively seek out new projects. We expect that many new DBPs will naturally evolve from the proposed work listed under the C&S section as those projects continue to take form. We will also continue to proactively seek out leaders in the fields of metabolism and biomedicine across a broad geographical area to initiate DBP projects that synergize with our existing work. We will continue to maintain a high bar for acceptance of DBP projects by actively screening proposals and selecting only those that we deem to be the most challenging and high-impact.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM108538-05
Application #
9988441
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Chen, Zhengwei; Yu, Qing; Hao, Ling et al. (2018) Site-specific characterization and quantitation of N-glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD). Analyst 143:2508-2519
Jiang, Xiaoyue; Xiang, Feng; Jia, Chenxi et al. (2018) Relative Quantitation of Neuropeptides at Multiple Developmental Stages of the American Lobster Using N, N-Dimethyl Leucine Isobaric Tandem Mass Tags. ACS Chem Neurosci 9:2054-2063
Lapointe, Christopher P; Stefely, Jonathan A; Jochem, Adam et al. (2018) Multi-omics Reveal Specific Targets of the RNA-Binding Protein Puf3p and Its Orchestration of Mitochondrial Biogenesis. Cell Syst 6:125-135.e6
Overmyer, Katherine A; Tyanova, Stefka; Hebert, Alex S et al. (2018) Multiplexed proteome analysis with neutron-encoded stable isotope labeling in cells and mice. Nat Protoc 13:293-306
Bucci, Michael D; Weisenhorn, Erin; Haws, Spencer et al. (2018) An Autophagy-Independent Role for ATG41 in Sulfur Metabolism During Zinc Deficiency. Genetics 208:1115-1130
Wang, Yirong; Weisenhorn, Erin; MacDiarmid, Colin W et al. (2018) The cellular economy of the Saccharomyces cerevisiae zinc proteome. Metallomics 10:1755-1776
Tanimura, Nobuyuki; Liao, Ruiqi; Wilson, Gary M et al. (2018) GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism. Dev Cell 46:581-594.e4
Riley, Nicholas M; Sikora, Jacek W; Seckler, Henrique S et al. (2018) The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins. Anal Chem 90:8553-8560
Frost, Dustin C; Rust, Clayton J; Robinson, RenĂ£ A S et al. (2018) Increased N,N-Dimethyl Leucine Isobaric Tag Multiplexing by a Combined Precursor Isotopic Labeling and Isobaric Tagging Approach. Anal Chem 90:10664-10669
MacGilvray, Matthew E; Shishkova, Evgenia; Chasman, Deborah et al. (2018) Network inference reveals novel connections in pathways regulating growth and defense in the yeast salt response. PLoS Comput Biol 13:e1006088

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