There are three aims for the Administration and Management of this BTRR: 1) to develop an effective organizational structure, 2) to effectively facilitate interactions within the BTRR team, and 3) to effectively manage the fiscal resources of the BTRR. This BTRR will be housed and will function in alliance with the National High Magnetic Field Lab (NHMFL) that is funded by the National Science Foundation Division of Material Research and the State of Florida. The NHMFL is a consortium of three institutions: Florida State University, University of Florida and Los Alamos National Lab. The facilities that form the basis for the TR&Ds in this proposal are NHMFL NMR facilities at UF in Gainesville (TR&D1) and at FSU in Tallahassee (TR&Ds 2 & 3). Consequently, this BTRR will be hosted by an extensive and well-functioning collaboration between FSU and UF that has developed over more than 25 years. The three PIs for this BTRR have more than a decade of experience partnering together to form an exemplary NMR user facility for the nation. This BTRR will represent a unique NIH Resource that develops novel technological NMR capabilities for the national biomedical research community. NMR is an exceptionally versatile tool with opportunities not only to look at many different nuclei, but even more combinations of nuclei and even more and varied experiments with any given set of nuclei. Managing the community's interests (demands) for new technology is challenging ? we know because the three of us mediate this discussion on such topics frequently. The probes that will be developed here represent major technological efforts. The team of three PIs (Brey, Long & Cross) coupled with our DBPs represents a team that can evaluate and prioritize the probe parameters that must be optimized and what parameters can be relaxed without sacrificing the highest priority science. This is why we have three PIs and will have weekly conference calls and why we have such a strong set of DBPs for each TR&D. In addition to managing the technological goals the operations of the TR&D facilities for DBPs and C&Ss will be managed by the PDs, the same as the PIs with the addition of Merritt. These PDs in combination with a group of post-docs and current NHMFL staff will facilitate the user experience by the DBPs and C&Ss. Research at the frontiers of the technology always brings excitement and frustration, frustration for the user and frustration for the staff. By having the technology team in house, repair time for instrumentation can be minimized. Having multiple probes for the spectrometers also minimizes spectrometer down time. Staff will generate monthly fiscal reports for review and approval by the PIs so that the financial resources are managed effectively. An External advisory committee will review annually the fiscal reports as will as the entire operation of the BTRR.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
1P41GM122698-01
Application #
9280020
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Florida State University
Department
Type
DUNS #
790877419
City
Tallahassee
State
FL
Country
United States
Zip Code
32306
von Morze, Cornelius; Reed, Galen D; Larson, Peder E et al. (2018) In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med 80:480-487
Dubroca, Thierry; Smith, Adam N; Pike, Kevin J et al. (2018) A quasi-optical and corrugated waveguide microwave transmission system for simultaneous dynamic nuclear polarization NMR on two separate 14.1?T spectrometers. J Magn Reson 289:35-44
Cao, Wei; Wang, Wei David; Xu, Hai-Sen et al. (2018) Exploring Applications of Covalent Organic Frameworks: Homogeneous Reticulation of Radicals for Dynamic Nuclear Polarization. J Am Chem Soc 140:6969-6977
von Morze, Cornelius; Merritt, Matthew E (2018) Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology. NMR Biomed :e3937
Wu, Cheng-Yang; Satapati, Santhosh; Gui, Wenjun et al. (2018) A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity. J Biol Chem 293:9604-9613
Gan, Zhehong; Hung, Ivan; Wang, Xiaoling et al. (2017) NMR spectroscopy up to 35.2T using a series-connected hybrid magnet. J Magn Reson 284:125-136
Keeler, Eric G; Michaelis, Vladimir K; Colvin, Michael T et al. (2017) 17O MAS NMR Correlation Spectroscopy at High Magnetic Fields. J Am Chem Soc 139:17953-17963
DeHaven, Baillie A; Tokarski 3rd, John T; Korous, Arthur A et al. (2017) Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy. Chemistry 23:8315-8319