We have identified nineteen collaboration and service projects for the National Resource for Advanced NMR Technology BTRR. This set of projects encompasses an impressive portfolio of projects supported by the NIH. They also have the resources needed at their home institutions to make challenging and biomedically relevant samples and to gather preliminary data to inform the experiments they will undertake in our facility. Equally important, these projects will benefit from unique technologies developed in each of the TR&D projects. Many of the projects will use capabilities developed in two, or even three, of the TR&D areas. The projects are all distinguished by a clear need for improved sensitivity and resolution beyond what conventional NMR instru- mentation can provide. All the C&S PIs have a well-defined vision for what they can accomplish as the ultrasensitive cryoprobes (TR&D1), dynamic nuclear polarization technologies (TR&D2), and capabilities for the series connected hybrid (SCH) magnet (TR&D3) are made available through our user program. In support of the C&S projects we have three specific aims for the BTRR: 1) assist users in utilizing new technology developed through the BTRR; 2) develop and refine technology through active engagement with the user community; 3) broaden the user base through outreach and active recruitment of new users. C&S projects were selected to provide broad coverage of biomedical research areas which can benefit from our BTRR. In addition, many of them are already actively engaged users of our facilities, which gives us great confidence they will truly fill the role intended for C&S projects.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Biotechnology Resource Grants (P41)
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Florida State University
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Cao, Wei; Wang, Wei David; Xu, Hai-Sen et al. (2018) Exploring Applications of Covalent Organic Frameworks: Homogeneous Reticulation of Radicals for Dynamic Nuclear Polarization. J Am Chem Soc 140:6969-6977
von Morze, Cornelius; Merritt, Matthew E (2018) Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology. NMR Biomed :e3937
Wu, Cheng-Yang; Satapati, Santhosh; Gui, Wenjun et al. (2018) A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity. J Biol Chem 293:9604-9613
von Morze, Cornelius; Reed, Galen D; Larson, Peder E et al. (2018) In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med 80:480-487
Dubroca, Thierry; Smith, Adam N; Pike, Kevin J et al. (2018) A quasi-optical and corrugated waveguide microwave transmission system for simultaneous dynamic nuclear polarization NMR on two separate 14.1?T spectrometers. J Magn Reson 289:35-44
Gan, Zhehong; Hung, Ivan; Wang, Xiaoling et al. (2017) NMR spectroscopy up to 35.2T using a series-connected hybrid magnet. J Magn Reson 284:125-136
Keeler, Eric G; Michaelis, Vladimir K; Colvin, Michael T et al. (2017) 17O MAS NMR Correlation Spectroscopy at High Magnetic Fields. J Am Chem Soc 139:17953-17963
DeHaven, Baillie A; Tokarski 3rd, John T; Korous, Arthur A et al. (2017) Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy. Chemistry 23:8315-8319