The primary mission of the Mouse Genome Database (MGD) is to facilitate the use of the mouse as a model system for understanding human biology and disease. To achieve this objective we: 1) create and maintain an integrated representation of mouse genetic, genomic, and phenotypic data;2) expertly curate and annotate data to develop definitive reference data sets and consensus views;3) gather and synthesize comparative genomic data between mouse and other mammals;4) maintain a rich set of links and collaborations with other bioinformatics resources;5) develop and support analysis and data submission tools;6) develop user-friendly interfaces for public access to mouse genomic data;7) provide extensive technical support for our community of database users;8) actively participate in a coordinate with the global research community. This renewal proposes a Program revolving around the themes of sequences, genes, and phenotypes. Sequences and Sequence Maps: We will enhance the representation of sequence data and maps. Sequences and sequence feature maps will be integrated into MGD, gene models will be collected to biological context, and map of objects will become an important mechanism for viewing and exploring MGD. Genes and Gene Products: We will continue curation of MGD's core data and expand these to include gene products and gene groupings. Core data include information about genes and variants, function and process, and mammalian homologies. Phenotypes: We will enhance the representation of phenotypes in MGD, develop controlled vocabularies for describing phenotypes, and gather and annotate phenotype data. Phenotypic data about single gene mutations, multigenic traits, QTL, disease models and strains data will be emphasized. Database and Software Development: We will provide a unified software effort and design and implement database and software changes to MGD to achieve the overall goals of the Program Project. Community Outreach: As the scientific community database for the mouse, MGD places high priority on community involvement. We provide technical support for our database users and encourage community input, submissions, annotations, and collaborations.

National Institute of Health (NIH)
National Human Genome Research Institute (NHGRI)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZHG1)
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Jackson Laboratory
Bar Harbor
United States
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Christie, Karen R; Blake, Judith A (2018) Sensing the cilium, digital capture of ciliary data for comparative genomics investigations. Cilia 7:3
Knowlton, Michelle N; Smith, Cynthia L (2017) Naming CRISPR alleles: endonuclease-mediated mutation nomenclature across species. Mamm Genome 28:367-376
Huntley, Rachael P; Sitnikov, Dmitry; Orlic-Milacic, Marija et al. (2016) Guidelines for the functional annotation of microRNAs using the Gene Ontology. RNA 22:667-76
Loughner, Chelsea L; Bruford, Elspeth A; McAndrews, Monica S et al. (2016) Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Hum Genomics 10:10
Shaw, David R (2016) Searching the Mouse Genome Informatics (MGI) Resources for Information on Mouse Biology from Genotype to Phenotype. Curr Protoc Bioinformatics 56:1.7.1-1.7.16
Bult, Carol J; Eppig, Janan T; Blake, Judith A et al. (2016) Mouse genome database 2016. Nucleic Acids Res 44:D840-7
Li, You; Klena, Nikolai T; Gabriel, George C et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521:520-4
Eppig, Janan T; Blake, Judith A; Bult, Carol J et al. (2015) The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease. Nucleic Acids Res 43:D726-36
Desvignes, T; Batzel, P; Berezikov, E et al. (2015) miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants. Trends Genet 31:613-626
Dolan, Mary E; Baldarelli, Richard M; Bello, Susan M et al. (2015) Orthology for comparative genomics in the mouse genome database. Mamm Genome 26:305-13

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