FlyBase is a long-term informatics resource that provides the scientific community with core genetic and genomic information on the major biomedical genetic model, Drosophila melanogaster, and other flies of the genus Drosophila. With the continuing explosion of information in major genome-wide datasets as well as the scientific literature, the role of a model organism database in capturing, organizing and distilling the key information is essential to researchers using Drosophila as their experimental system, to groups using the results of Drosophila research to inform their studies on other systems (including researchers focusing on humans), and to computational biologists who require such comprehensive, well structured data sources. FlyBase will continue to curate the scientific literature, annotate the D. melanogaster genome through expert manual curation, annotate the other Drosophila species by a combination of automatic and selective manual approaches, and capture large-scale functional genomics datasets. These diverse sets of data will be integrated within the FlyBase database and presented to the public through regular monthly updates to the FlyBase website ( FlyBase thus serves as one of the public portals to data produced by a variety of sequencing and functional genomics projects supported by NHGRI and the other institutes of NIH, as well as by other U.S. and international funding agencies, and to the research literature that is produced in part by taking advantage of these major datasets. Joining the three currently participating FlyBase sites for this renewal is a group at the University of New Mexico which will play a central role in the FlyBase Minority Action Plan.

Public Health Relevance

Research on Drosophila melanogaster continues to be at the forefront of studies of biological pathways and networks in the context of cell and developmental biology, neurobiology and behavioral biology. It has also been one of the most significant systems for studying variation, complex traits, population biology, ecology and evolution. The insights from Drosophila research are of direct importance to human health research, both because of the tremendous similarities between the Drosophila and human gene sets and biological processes, allowing Drosophila research to inform studies of human biology and disease, but also because Drosophila melanogaster is the closest model for research on insect vectors of disease.

National Institute of Health (NIH)
National Human Genome Research Institute (NHGRI)
Biotechnology Resource Grants (P41)
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Ethical, Legal, Social Implications Review Committee (GNOM)
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Good, Peter J
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Harvard University
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Attrill, Helen; Falls, Kathleen; Goodman, Joshua L et al. (2016) FlyBase: establishing a Gene Group resource for Drosophila melanogaster. Nucleic Acids Res 44:D786-92
Crosby, Madeline A; Gramates, L Sian; Dos Santos, Gilberto et al. (2015) Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. G3 (Bethesda) 5:1737-49
Matthews, Beverley B; Dos Santos, Gilberto; Crosby, Madeline A et al. (2015) Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. G3 (Bethesda) 5:1721-36
dos Santos, Gilberto; Schroeder, Andrew J; Goodman, Joshua L et al. (2015) FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations. Nucleic Acids Res 43:D690-7
Gene Ontology Consortium (2015) Gene Ontology Consortium: going forward. Nucleic Acids Res 43:D1049-56
St Pierre, Susan E; Ponting, Laura; Stefancsik, Raymund et al. (2014) FlyBase 102--advanced approaches to interrogating FlyBase. Nucleic Acids Res 42:D780-8
Cejuela, Juan Miguel; McQuilton, Peter; Ponting, Laura et al. (2014) tagtog: interactive and text-mining-assisted annotation of gene mentions in PLOS full-text articles. Database (Oxford) 2014:bau033
Hoehndorf, Robert; Hardy, Nigel W; Osumi-Sutherland, David et al. (2013) Systematic analysis of experimental phenotype data reveals gene functions. PLoS One 8:e60847
Marygold, Steven J; Leyland, Paul C; Seal, Ruth L et al. (2013) FlyBase: improvements to the bibliography. Nucleic Acids Res 41:D751-7
Latham, Kristin L; Liu, Ying-Show; Taylor, Barbara J (2013) A small cohort of FRU(M) and Engrailed-expressing neurons mediate successful copulation in Drosophila melanogaster. BMC Neurosci 14:57

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