Caenorhabditis elegans is a major model system for basic biological and biomedical research and the first animal for which there is a complete description of its genome, anatomy and development. Five years of funding is requested to maintain and expand WormBase, a Model Organism Database (MOD), with complete coverage of core genomic, genetic, anatomical and functional information about this nematode. Such a database is necessary to allow the entire biomedical research community as well as C. elegans researchers to make full use of the 100 Mb genomic sequence, with its 19,500 genes, the 108 Mb sequence of C. briggsae, and the results of intensive molecular genetic analysis of C. elegans. The two top priorities will be intensive data curation and user interface improvement. WormBase will include up-to-date annotation of the genomic sequence, the current genetic and physical maps and many experimental data connected to the function and interactions of cells and genes, as well as development and organismal behavior. Direct access to the sources of biological material, such as the strain collection of the Caenorhabditis genetics Center and direct links to data sets maintained by others will be provided. Data will be recovered from the existing resources, from direct contribution of the individual laboratories, and from the literature. While WormBase will act as a central forum through which every laboratory will be able to contribute constructively to the global effort to fully comprehend this metazoan organism, WormBase professional curators will ensure detailed attribution of data sources and check consistency and integrity. To facilitate communication WormBase will use wherever possible terminology and style concordant with other model organism databases. WormBase will be Web based and easy to use. Multiple databases will be used for data management; the object-based Acedb database system will be used for integration, and this integrated database plus """"""""slave"""""""" relational databases will be used to drive the website. Coordination of the project and the main curation site will be at Caltech under the supervision of a C. elegans biologist. Curation and annotation of genomic sequence will take place at the two sequencing centers, the Sanger Institute and Washington University that generated the entire genome sequence. Development of enhanced user interfaces will take place at Cold Spring Harbor. WormBase will work with other MODs to develop shared schema and software (the Generic Model Organism Database project), and shared ontologies (Gene Ontology Consortium).
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