Affinity MS is being used extensively in a detailed series of studies concerning proteolytic degradation of P-amyloid protein AD). In particular, the new approach is being used to help: Identify proteolytic fragments of AD in cultured cells. Measure degradation rates for AD 1 -40 and A P 1 -42. Characterize proteolytic enzymes involved in AD degradation. Examine pH dependency of proteolytic degradation of AD. Correlate proteolytic AD degradation and AD peptide composition in Alzheimer's disease patient's brain.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000862-27
Application #
6307551
Study Section
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
27
Fiscal Year
2000
Total Cost
$8,199
Indirect Cost
Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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