The primary research goal is to define, molecular, and functional nature of antigenic peptides presented as HLA class I antigens and to evaluate their clinical significance. Studies are focused on peptides on renal allograft rejection, autoimmune renal diseases and breast and lung cancers. We are isolating HLA class I bound peptides from tumor cells using reverse phase HPLC, identifying biologically active fractions and analyzing them by capillary LC/MS and product ion spectra using database search algorithms to sequence the peptide and identify the protein source.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000954-22
Application #
6118568
Study Section
Project Start
1998-08-01
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
22
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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