An efficient one-pot synthetic route to JM3100 (AMD3100), a highly potent inhibitor of HIV multiplication entering clinical trials, is reported based on temporary protection of the cyclam followed by reaction with P,P'-dibromoxylene and deprotection to give the bis-cyclam. This route can readily be adapted to the production of analogs of JM3100.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000954-24
Application #
6336768
Study Section
Project Start
2000-08-01
Project End
2001-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
24
Fiscal Year
2000
Total Cost
$10,290
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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