This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sphingolipids are a diverse family of phospholipids of high abundance among all eukaryotic cell membranes. Functions of sphingolipids include the formation of lipid rafts, mediation of cell-cell interaction, and participation in signal transduction. In this study roles of de novo sphingolipid biosynthesis in protozoan parasites Leishmania were evaluated by deleting the serine palmitoyltransferase 2 (SPT2) gene, which encodes for one of the two essential subunits of serine palmitoyltransferease, the first enzyme of sphingoloipid biosynthesis pathway. These data demonstrate that de novo sphingolipid biosyntheseis plays vital roles in Leishmania differentiation and virul
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