This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of my laboratory's research is to develop new methods of studying cellular function. The research embraces chemistry and biology, using organic synthesis as a tool for understanding, controlling, and manipulating cell physiology. In an approach that is complementary to genetic techniques, small organic molecules can be designed and synthesized to probe biological systems, thereby providing information about how they work. Understanding the mechanisms of cellular function appends our knowledge of the diversity and complexity of life and is necessary for medical intervention in disease states. The work is multidisciplinary in nature, involving organic synthesis, biochemistry, photophysics applied in a biological context, and some molecular and cellular biology. The research program has thrusts in three major areas: photochemistry, kinesin motor proteins, and CaaX proteins
Showing the most recent 10 out of 696 publications
