This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Many cells express a Group VIA phospholipase A2, designated iPLA2B, that does not require calcium for activation, is stimulated by ATP, and is sensitive to inhibition by a bromoenol lactone suicide substrate (BEL). Studies in various cell systems have led to the suggestion that iPLA2B has a role in phospholipids remodeling, signal transduction, cell proliferation, and apoptosis. We have found that pancreatic islets, B-cells, and glucose-responsive insulinoma cells express an iPLA2B that participates in glucose-stimulated insulin secretion but is not involved in membrane phospholipids remodeling. Additionally, recent studies reveal that iPLA2B is involved in pathways that contribute to B-cell proliferation and apaptosis, and that various phospholipid-derived mediators are involved in these processes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000954-31
Application #
7721455
Study Section
Special Emphasis Panel (ZRG1-BPC-H (40))
Project Start
2008-02-01
Project End
2009-01-31
Budget Start
2008-02-01
Budget End
2009-01-31
Support Year
31
Fiscal Year
2008
Total Cost
$8,880
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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