We are working on solving the structure of protease and protease inhibitor complexes. Proteases play important roles in many biological processes. Understanding the mechanism of their action is of great significance to drug discovery. We are using X-ray crystallography to elucidate the interaction between various mutants of ecotin and different types of proteases. It helps us understand the amazing ability of ecotin to inhibit various serine protease, hence gives us insight in designing inhibitors for proteases that are involved in various diseases. The graphic facilities in the Computer Graphics Laboratory are of great use for my research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001081-21
Application #
6280274
Study Section
Project Start
1998-07-01
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
21
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kozak, John J; Gray, Harry B; Garza-López, Roberto A (2018) Relaxation of structural constraints during Amicyanin unfolding. J Inorg Biochem 179:135-145
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Papale, Alessandro; Morella, Ilaria Maria; Indrigo, Marzia Tina et al. (2016) Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors. Elife 5:

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