This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The RBVI is engaged in a wide variety of training and dissemination activities for our various software tools and web resources. These include: UCSF Chimera, the Structure-Function Linkage Database, BayGenomics, IGTC, PMT, as well as our Cytoscape and general informatics activities. Currently, the bulk of our training and dissemination is focused on UCSF Chimera.UCSF Chimera is the molecular modeling package under active development by the UCSF Computer Graphics Lab. Chimera is a tool for visualization and analysis of biomolecular structures and interactions. In addition to atomic coordinates, it can be used to explore other data types such as electron density maps, electrostatic potential maps, and sequence alignments, and it can be used to create high-quality images for publication and presentation.As development continues, it is imperative that the Chimera team remains connected to the broader structural and molecular biology research and teaching community through outreach and training. These activities promote awareness of what Chimera has to offer, resulting in more effective use and frequently culminating in further developments.While Chimera remains a significant focus of our training and dissemination activities (and development activities, for that matter), we also are active in presentations about SFLD and Cytoscape, tutorials for the PGA, and presentations about the broad activities of the RBVI that tie many of our projects together.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR001081-30
Application #
7597775
Study Section
Special Emphasis Panel (ZRG1-BST-D (40))
Project Start
2007-08-13
Project End
2008-06-30
Budget Start
2007-08-13
Budget End
2008-06-30
Support Year
30
Fiscal Year
2007
Total Cost
$41,325
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kozak, John J; Gray, Harry B; Garza-López, Roberto A (2018) Relaxation of structural constraints during Amicyanin unfolding. J Inorg Biochem 179:135-145
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Sofiyev, Vladimir; Kaur, Hardeep; Snyder, Beth A et al. (2017) Enhanced potency of bivalent small molecule gp41 inhibitors. Bioorg Med Chem 25:408-420
Kozak, John J; Gray, Harry B; Garza-López, Roberto A (2016) Cytochrome unfolding pathways from computational analysis of crystal structures. J Inorg Biochem 155:44-55
Amlong, Corey A; Perkins, Mark G; Houle, Timothy T et al. (2016) Contrasting Effects of the ?-Aminobutyric Acid Type A Receptor ?3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB. Anesth Analg 123:1241-1246

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