This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The advent of the web has had a significant and lasting impact on the practice of Science. Data, results, procedures, and scientific information can be downloaded, or viewed as text with static images. To view graphical data interactively on the web has required special plug-in technologies or Java applets which increase the complexity and hurdles to access. Recent standards activities by the W3C promise to ameliorate these hurdles through a rich declarative graphical language similar to HTML called Scalable Vector Graphics (SVG). SVG is already widely implemented in graphics packages such as Visio, Photoshop, and Illustrator, but has not been available through a web browser without the addition of a plug-in. Through collaboration with the open-source web-browser development community, we are extending the functionality of the Mozilla-based browsers (e.g., Firefox, Mozilla) to support the use of SVG for visualization of graphical data. With the release of SVG as a native component of Firefox, text and images within HTML will be able to be mixed with scalable vector graphics described via SVG. This will be used to enhance the access to scientific resources and information provided by RBVI. For example, we plan to implement a chromatogram viewer for the display of DNA sequence """"""""traces"""""""" directly within a web-browser. This will directly benefit two collaborative projects within the RBVI, the Pharmacogenetics of Membrane Transporters (PMT) and BayGenomics, as well as be very useful to the general DNA sequencing community.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001081-33
Application #
8170528
Study Section
Special Emphasis Panel (ZRG1-BST-D (40))
Project Start
2010-07-01
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
33
Fiscal Year
2010
Total Cost
$26,648
Indirect Cost
Name
University of California San Francisco
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kozak, John J; Gray, Harry B; Garza-López, Roberto A (2018) Relaxation of structural constraints during Amicyanin unfolding. J Inorg Biochem 179:135-145
Alamo, Lorenzo; Pinto, Antonio; Sulbarán, Guidenn et al. (2018) Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease. Biophys Rev 10:1465-1477
Viswanath, Shruthi; Chemmama, Ilan E; Cimermancic, Peter et al. (2017) Assessing Exhaustiveness of Stochastic Sampling for Integrative Modeling of Macromolecular Structures. Biophys J 113:2344-2353
Chu, Shidong; Zhou, Guangyan; Gochin, Miriam (2017) Evaluation of ligand-based NMR screening methods to characterize small molecule binding to HIV-1 glycoprotein-41. Org Biomol Chem 15:5210-5219
Portioli, Corinne; Bovi, Michele; Benati, Donatella et al. (2017) Novel functionalization strategies of polymeric nanoparticles as carriers for brain medications. J Biomed Mater Res A 105:847-858
Alamo, Lorenzo; Koubassova, Natalia; Pinto, Antonio et al. (2017) Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function. Biophys Rev 9:461-480
Nguyen, Hai Dang; Yadav, Tribhuwan; Giri, Sumanprava et al. (2017) Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1. Mol Cell 65:832-847.e4
Sofiyev, Vladimir; Kaur, Hardeep; Snyder, Beth A et al. (2017) Enhanced potency of bivalent small molecule gp41 inhibitors. Bioorg Med Chem 25:408-420
Nekouzadeh, Ali; Rudy, Yoram (2016) Conformational changes of an ion-channel during gating and emerging electrophysiologic properties: Application of a computational approach to cardiac Kv7.1. Prog Biophys Mol Biol 120:18-27
Towse, Clare-Louise; Vymetal, Jiri; Vondrasek, Jiri et al. (2016) Insights into Unfolded Proteins from the Intrinsic ?/? Propensities of the AAXAA Host-Guest Series. Biophys J 110:348-361

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