Our objective was to determine the feasibility of selective photosensitization of vulvar condylomata using topical application of 5-aminolevulinic acid (ALA). In vivo fluorescence was assessed and biopsies of condylomata were taken for fluorescence microscopy in 24 patients at different time points after application of 2.5% ALA-ointment or 20% ALA-cream. Both in vivo fluorescence imaging and fluorescence microscopy showed selective fluorescence of condylomata of the labia minora and vestibule only within short time intervals. In non-hair-bearing skin, lesional fluorescence remained highly selective. Fluorescence microscopy showed that peak selectivity in epithelial lesional fluorescence was significantly higher using 2.5% ALA-ointment than it was using the 20% cream. Selective fluorescence of vulvar condylomata acuminata can be induced by non-selective topical ALA application. Studies evaluating selective photodynamic destruction of condylomata are justified.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001192-17
Application #
5222609
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
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