Abstract

We propose a series of investigations to test the feasibility of frequency domain photon migration (FDPM) as a method for noninvasive determination of the integrity of silicone (polydimethylsiloxane, PDMS) filled breast implants and the physiologic changes related to these implants. The existing FDPM apparatus currently employed at the Laser Microbeam and Medical Program (LAMMP) for noninvasive studies of breast lesions will be with the addition of a laser diode matched to the absorption band if silicone. Experiments will involve collection of FDPM data from tissue phantoms containing scatterer and absorber in addition to silicone in order to establish accuracy and sensitivity of the method to silicone detection and quantification. Silicone concentrations will be calculated using both classical least squares and partial least squares (PLS) methods. After characterization of silicone specific FDPM in vitro, experimentation on patients scheduled for explant surgery can b e performed. This technology, if shown to be feasible, would provide a noninvasive tool that could be used to assist in enumeration of the health risks associated with silicone filled implants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001192-20
Application #
6119318
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
20
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Paugh, Jerry R; Alfonso-Garcia, Alba; Nguyen, Andrew Loc et al. (2018) Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy. Ocul Surf :
Verdel, Nina; Lentsch, Griffin; Balu, Mihaela et al. (2018) Noninvasive assessment of skin structure by combined photothermal radiometry and optical spectroscopy: coregistration with multiphoton microscopy. Appl Opt 57:D117-D122
Friedman, Jacob E; Dobrinskikh, Evgenia; Alfonso-Garcia, Alba et al. (2018) Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun 2:313-328
Kennedy, Gordon T; Lentsch, Griffin R; Trieu, Brandon et al. (2017) Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics. J Biomed Opt 22:76013
Takesh, Thair; Sargsyan, Anik; Lee, Matthew et al. (2017) Evaluating the Whitening and Microstructural Effects of a Novel Whitening Strip on Porcelain and Composite Dental Materials. Dentistry (Sunnyvale) 7:
Jonscher, Karen R; Stewart, Michael S; Alfonso-Garcia, Alba et al. (2017) Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J 31:1434-1448
Alfonso-García, Alba; Paugh, Jerry; Farid, Marjan et al. (2017) A machine learning framework to analyze hyperspectral stimulated Raman scattering microscopy images of expressed human meibum. J Raman Spectrosc 48:803-812
Takesh, Thair; Sargsyan, Anik; Anbarani, Afarin et al. (2017) Effects of a Novel Whitening Formulation on Dental Enamel. Dentistry (Sunnyvale) 7:
Choi, Bernard; Tan, Wenbin; Jia, Wangcun et al. (2016) The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities. IEEE J Sel Top Quantum Electron 2016:
Wang, Mingqiu; Ravindranath, Shreyas R; Rahim, Maha K et al. (2016) Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions. Langmuir 32:13124-13136

Showing the most recent 10 out of 663 publications