Despite the utility of conventional neuroimaging (MRI and CT scanning), some diagnostic conundrums remain in the neurological disorders. We describe an optical diagnostic tool to extract biochemical information from neurological tissues using Frequency Domain Photon Migration (FDPM). This low-power laser device devised at the LAMMP has been used to study patients with brain tumors at UCIMC. We have characterized normal and abnormal neurological tissues in vivo during neurosurgery operations and located physiological differences between diseased and normal states, locally. This technique provides a non-invasive or minimally invasive adjunct to current neurological diagnostics and in the future, a functional monitor of neurological physiology.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001192-21
Application #
6308200
Study Section
Project Start
2000-04-01
Project End
2001-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
21
Fiscal Year
2000
Total Cost
$24,634
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Paugh, Jerry R; Alfonso-Garcia, Alba; Nguyen, Andrew Loc et al. (2018) Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy. Ocul Surf :
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