The broad, long term objective is to develop a noninvasive optical technique for imaging in vivo blood flow dynamics and tissue structure with high spatial resolution in biological systems.
The specific aims are to 1) Develop a dedicated, portable high speed ODT instrument for tomographic imaging of in vivo blood flow dynamics and tissue structure in highly scattering biological tissues, 2) Develop a signal processing and image construction algorithm for high speed ODT, 3) Investigate the effects of multiple scattering and coherence gating on ODT images by simulating light absorption and scattering in turbid fluid flow media using Monte Carlo methods, 4) Image in vitro blood flow using reconstituted canine blood to verify and optimize the operation and spatial resolution of the ODT system and 5) Image in vivo blood flow in animal models and humans to demonstrate the potential clinical applications of the technique.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001192-22
Application #
6438800
Study Section
Project Start
2001-04-01
Project End
2002-03-31
Budget Start
Budget End
Support Year
22
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Paugh, Jerry R; Alfonso-Garcia, Alba; Nguyen, Andrew Loc et al. (2018) Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy. Ocul Surf :
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Takesh, Thair; Sargsyan, Anik; Anbarani, Afarin et al. (2017) Effects of a Novel Whitening Formulation on Dental Enamel. Dentistry (Sunnyvale) 7:
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