We are interested in making FDPM measurements to probe layered tissue structures as well as assess the properties of small tissue volumes.
The specific aims are 1) Generalize standard optical diffusion theory (SODT) to provide governing equations which accommodate spatially distributed collimated sources, 2) Solve these new equations for steady and amplitude-modulated collimated point sources located within an infinite medium. Compare results to solutions derived using SODT and experimental measurement, 3) Solve the new equations for steady and amplitude-modulated collimated sources illuminating the surface of an infinite medium. Compare results with SODT and experiment, and 4) Develop a theoretical framework to address cases where FDPM measurements contain significant contributions from both minimally scattered and fully diffuse photons.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001192-23
Application #
6586463
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
23
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Paugh, Jerry R; Alfonso-Garcia, Alba; Nguyen, Andrew Loc et al. (2018) Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy. Ocul Surf :
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Alfonso-García, Alba; Paugh, Jerry; Farid, Marjan et al. (2017) A machine learning framework to analyze hyperspectral stimulated Raman scattering microscopy images of expressed human meibum. J Raman Spectrosc 48:803-812
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Choi, Bernard; Tan, Wenbin; Jia, Wangcun et al. (2016) The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities. IEEE J Sel Top Quantum Electron 2016:

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