This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. High resolution CT images can now find small nodules in lung tissue. It is difficult to pinpoint the exact location of these small nodules from the CT scan during surgery. As chest surgery becomes less invasive there exists the possibility of using optical methods to search for nodules in lung. The current state of research is to determine whether optical identification and characterization of lung masses at clinically relevant depths is feasible using frequency Domain Photon Migration. This is difficult since (1) the optical properties of lung tissue are not well known, and (2) lung optical properties change with ventilation.
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