This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This proposal outlines two development efforts which are key to the intelligent integration of multi-component technologies in microfluidic systems, and of great importance to the maturation of microfluidics engineering and manufacturing in general. These are the development of a sophisticated, automated microfluidic probe station, and the subsequent use of that tool for the systematic study of non-ideal, non-homogeneous biological fluids such as blood in microfluidic chips. The probe station technology will allow for automated, high throughput testing and evaluation of microfluidic chips during and after manufacturing. The in-depth fluidics study will provide a better understanding of non-ideal, non-homogeneous fluid flow in common chip components by providing the experimental data needed for perfecting accurate modeling algorithms and providing databases needed for the device libraries of computer aided design software. This important study would not be possible without the development of the automated microfluidic probe station.
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