This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The upper airway is uniquely accessible for multimodality high resolution imaging to provide information on extent of exposure and lower airway risks injury. The objective of this proposal is to assess upper airway high resolution multimodality optical imaging based on real-time fiberoptic functional F-OCT and MPM of the upper airway as a means for diagnosis of inhalation injury and treatment in the entire airway. Upon completion of this airway injury project the following will have been delivered: 1) a rapid, reproducible in-vitro model to investigate toxic gas exposures and interventions will be available; 2) fully functional airway OCT methodologies will have been developed, and 3) the potential capabilities of high resolution multimodality imaging with F-OCT, and MPM/SHG in improving early diagnosis, staging, and treatment of upper airway and endobronchial airway injury will have been demonstrated. IACUC2002-2397
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