This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Examples for optical medical diagnostic are the use of transillumination spectroscopy breast spectroscopy (TIBS) combined with numerical biostatistical methods to quantify the cancer risk. This work is based on the theory of tissue field transformation prior to the development of dysplasia and carcinoma in situ. To establish optical transillumination as a cancer risk assessment tool cross sectional clinical studies are under way or planned using an established epidemiological marker as gold standard. In the case of breast cancer this marker is the parenchymal density pattern as observed in standard mammography. Transillumination spectra show high sensitivity and specificity to classify women as having high or low parenchymal density pattern. We have combined measurements of TIBS with DOS to better understand the origins of optical signals in breast that contribute to risk. Both normal and cancer patients will be studied .
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