This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Blood flow contrast between tumor and normal tissues in patients with malignant and benign breast cancer has been measured by diffuse optical correlation methods. The measurements were carried out with a hand-held optical probe that was manually scanned over the tumor-bearing breast. Increased blood flow was observed in tumor regions relative to healthy tissue, and control subjects did not exhibit significant blood flow heterogeneity. The measurements introduce a new optical contrast for diffuse optical mammography.Measurements of blood flow have been combined with DOS to better understand the origins of contrast in breast tumors. Specifically, we are interested in determining how static and dynamic optical properties will change in response to anti-tumor therapies.
Showing the most recent 10 out of 663 publications