This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Water is an important common molecule in tissues whose importance is often underestimated. The absorption spectrum of water is a sensitive marker of many important physiological conditions in tissues relevant to cancer. It is hypothesized that the biochemical state of water changes between normal and cancer tissues. Evidence for this comes directly from extensive diffusion weighted MRI measruements of breast tumors.We propose to investigate the role of bound and free waters in the detrmination of breast cancer. The concentrations of bound and free waters may explain the balance of extracellular and intracellular waters, and thus provide a window into the cellular state of tumors. Changes in bound/free water state may also be useful in measuring response to cancer theapies.
Showing the most recent 10 out of 663 publications