This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This work will construct a handheld instrument for noninvasive detection of breast cancer based on a broad-band optical spectroscopy technique called frequency-domain photon migration (FDPM). It will perform broad-band modulation on the intensity of near-infrared laser diodes and derives the scattering and absorption coefficients of the bulk tissue from phase and amplitude data measurements. The miniature size makes it possible to eliminate fiberoptic cables and enables direct contact between the laser diode and the tissue, making the instrument more power efficient while enhancing detection capabilities. Measurement results show that these miniature systems match the current prototype while costing two orders of magnitude less.
Showing the most recent 10 out of 663 publications