This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study will be to verify the potential worth of non-invasive Optical Coherence Tomography (OCT), Optical Doppler Tomography (ODT), and Modulated Imaging (MI) for visualization, characterization of TMJ tissues including articular disc and bony components. This will be performed in vivo in hamsters in which TMD is induced by bonding metal orthodontic wire (0.91 mm diameter) on the biting surfaces of the lower right posterior teeth. This metal wire can induce unbalanced chewing, which is one of the major causes of TMD. The different response of TMJ between gender and the effects of aging also will be evaluated. After imaging, all of the data will be compared with histologic evaluation. Long-term goal of this study is to use non-invasive optical diagnostic devices including OCT, ODT, and MI to diagnose initial signs of TMD which is difficult to be identified with conventional diagnostic aids, and to prevent pathologic progresses as soon as possible. Our first studies will use a standard hamster model without TMD, to identify the best wavelength (400-1400nm) for optimizing OCT, ODT, and MI imaging. Then both right and left TMJ will be evaluated by using needle type probe for OCT and ODT, and a non-invasive hand-held probe for MI. Imaging will be done every week for 10 weeks.
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