RNA Pseudoknot From Beet Western Yellow Virus: Potent Inhibitor of HIV Rt

Rich, Alexander

Abstract

The RNA pseudoknot is an essential folding motif found in many classes of ribonucleic acids. Pseudoknot structures are involved in translational frameshifting, and they are found in the catalytic RNA component of RnaseP, and the cleavage site of the Hepatitis Delta Virus. Recent evidence shows that pseudoknots are potent inhibitors of the reverse transcriptase of HIV. To date, no crystal structrure is available to elucidate the detailed molecular geometry and tertiary interactions of the pseudoknot.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Biotechnology Resource Grants (P41)
• Project #: 5P41RR001209-17
• Application #: 5222798
• Support Year: 17
• Fiscal Year: 1996

Publications

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Yoshizawa, Takuya; Ali, Rustam; Jiou, Jenny et al. (2018) Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell 173:693-705.e22

Kupitz, Christopher; Olmos Jr, Jose L; Holl, Mark et al. (2017) Structural enzymology using X-ray free electron lasers. Struct Dyn 4:044003

VanderLinden, Ryan T; Hemmis, Casey W; Yao, Tingting et al. (2017) Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism. J Biol Chem 292:9493-9504