The receptor-related protein (RAP) competes with all known ligands of the low density lipoprotein receptor family, particularly the low density receptor-related protein (LRP) or the ?2-macroglobulin receptor. Initially, it was thought that RAP might function as a modulator of cell surface receptors; however, there is strong evidence that this protein likely functions in receptor folding and/or trafficking, serving as a new class of chaperones. The protein was crystallized from ammonium phosphate solutions as thin plates with a tendency to form clusters or twinned crystals. This unfavorable morphology does not allow us to use a standard approach x-ray investigation. Attempts to improve the morphology of the crystals were unsuccessful. Synchrotron intense x-ray beam is the only means to collect data from these thin crystals.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001209-20
Application #
6119362
Study Section
Project Start
1999-03-01
Project End
2000-04-14
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
20
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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