Kinesin is the premier member of the family of microtubule-associated force-producing proteins which use ATP hydrolysis for power generation. We have crystallized the motor domain of the human kinesin heavy chain in order to obtain an X-ray structure of this region. Since there currently exists no high resolution structure for a kinesin-like protein, a structure of this domain would set the stage for an in depth exploration of ATP hydrolysis-driven protein motor activity.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001209-23
Application #
6586538
Study Section
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
23
Fiscal Year
2002
Total Cost
$143,176
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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