This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Natural products, including terpenoids, have historically provided the compounds used most successfully as leads for pharmaceutical, agricultural, and other commercial applications. The objectives of our research is to understand the structural, functional and chemical features governing: 1) the biosynthesis of IPP, the universal building unit for the biosynthesis of isoprenoids, via the recently discovered MEP pathway, involving the proteins DXS, DXR, YgbP, YchB, YgbB, GcpE and LytB 2) the conversion of IPP to its isomer, DMAPP, by type II IPP isomerases 3) the catalysis of FPPS enzyme 3) the mechanisms of FPP cyclization by terpene cyclases.
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