This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Beam time is requested for crystallographic analysis of G-protein coupled receptors (GPCRs). Our first experiments will be carried out on rhodopsin, the GPCR involved in the first molecular steps in vision. New crystal forms will be analyzed to observe the conformational change leading to signal transduction. These experiments will have considerable impact on drug design efforts for other GPCRs making up about a third of all current drug targets.
Showing the most recent 10 out of 604 publications