This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In studies performed during our previous proposals, we have been employing variable energy photoelectron spectroscopy in the valence and metal 2p regions to explore electronic relaxation, the change in electronic structure upon ionization of a reduced site. Thus far, this has been applied to Fe(SR)4 sites where the large electronic relaxation (ligand to M d CT) limits the charge change on oxidation and greatly reduces the geometry change (i.e. the reorganization energy of the site). We are now completing studies on a series of mononuclear Fe complexes in which we examined the effects of going from high to low spin and increased coordination number (tetrahedral vs. octahedral) as well as ligand variation to understand the contribution of heme ligation to electronic relaxation in the [Fetpp(imH)2] complex. We are now proposing to extend our PES studies of the bis-Im heme complex to the bis-met Fe(THT)2(tpp) complex and a cytochrome c model complex (Fe(C5-Im)(tpp)(THS).C6H6) where we will quantitate the effect of the met ligands on electronic relaxation and extend those results to electronic relaxation of cyt b vs. cyt c through DFT calculations and extended charge decomposition and valence bond configuration interaction analyses. In addition to PES studies of heme electron transfer sites, we will investigate covalency and electron delocalization and their contribution to electronic relaxation in blue copper, CuA, and Fe4S4 related model complexes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR001209-31
Application #
8170322
Study Section
Special Emphasis Panel (ZRG1-BCMB-P (40))
Project Start
2010-05-01
Project End
2011-02-28
Budget Start
2010-05-01
Budget End
2011-02-28
Support Year
31
Fiscal Year
2010
Total Cost
$346
Indirect Cost
Name
Stanford University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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