Abstract

(Supported in part by ACS PRF28650-AC7 to B. Naumann) The primary focus of this study is to acquire information to apply towards the production of blended polymers with optimal properties and therefore, improved functionality. The materials being studied have a wide range of uses in the biomedical field including the acetabulum in total hip replacement. Other applications include dentures and filling material, bone cement and medical packaging. One ongoing study involves the comparison of various polymers performance in impact energy testing. Samples are also being compared on a morphological basis in order to accurately determine the size distribution of particles over a large range of diameters and to determine the 3-D spatial relationships of the particles in the polymer material. The particles range from 2 micrometers to a few tenths of micrometers. The HVEM is the only instrument that can image this entire range and provide the critical 3-D information. Specimens are prepared by cryosectioning and observed in the HVEM at room temperature. Investigations were made with staining techniques to differentiate the different phases. The stain differential in PS/PB/R706 was excellent after modifying the RuOs4 staining procedure. We are currently analyzing the particle size of this blend.. We also observed that in the blend PMMA/PS/PB, the PMMA component is not compatible with the PB, therefore, R740 is not fully at interface. This result agrees with a previous study. In the PS/PB/Ran 48% polymer blend, it was determined that the Ran 48% is at the interface. Hundreds of stereo images were digitized for analysis at RPI, and two papers have been accepted for publication. Timothy J. Cavanaugh, K. Buttle, J. N. Turner and E. Bruce Nauman (1997) Confirmation of Predicted Polymer Blend Morphologies from Bulk Specimens. Polymer Cavanaugh, T.J., K. Buttle, J.N. Turner and DE.B. Nauman. (1997) The study of various styrene-butadiene copolymers as compatibilizers in bulk blends of polystyrene/ polybutadine. Polymer

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001219-17
Application #
6280692
Study Section
Project Start
1998-01-01
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
17
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Wadsworth Center
Department
Type
DUNS #
110521739
City
Menands
State
NY
Country
United States
Zip Code
12204

  Publications

Booth, David M; Enyedi, Balázs; Geiszt, Miklós et al. (2016) Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface. Mol Cell 63:240-248
Mannella, Carmen A; Lederer, W Jonathan; Jafri, M Saleet (2013) The connection between inner membrane topology and mitochondrial function. J Mol Cell Cardiol 62:51-7
Takvorian, Peter M; Buttle, Karolyn F; Mankus, David et al. (2013) The multilayered interlaced network (MIN) in the sporoplasm of the microsporidium Anncaliia algerae is derived from Golgi. J Eukaryot Microbiol 60:166-78
Forbes, Stephen J; Martinelli, Daniel; Hsieh, Chyongere et al. (2012) Association of a protective monoclonal IgA with the O antigen of Salmonella enterica serovar Typhimurium impacts type 3 secretion and outer membrane integrity. Infect Immun 80:2454-63
Wang, Ruiwu; Zhong, Xiaowei; Meng, Xing et al. (2011) Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. J Biol Chem 286:12202-12
Marko, Michael; Leith, Ardean; Hsieh, Chyongere et al. (2011) Retrofit implementation of Zernike phase plate imaging for cryo-TEM. J Struct Biol 174:400-12
Springer, Deborah J; Ren, Ping; Raina, Ramesh et al. (2010) Extracellular fibrils of pathogenic yeast Cryptococcus gattii are important for ecological niche, murine virulence and human neutrophil interactions. PLoS One 5:e10978
Li, Chunhao; Sal, Melanie; Marko, Michael et al. (2010) Differential regulation of the multiple flagellins in spirochetes. J Bacteriol 192:2596-603
McEwen, Bruce F; Dong, Yimin (2010) Contrasting models for kinetochore microtubule attachment in mammalian cells. Cell Mol Life Sci 67:2163-72
Palladino, Michael J (2010) Modeling mitochondrial encephalomyopathy in Drosophila. Neurobiol Dis 40:40-5

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