The broad objectives of this project are 1) to define the limites of static SIMS in the quantitative monitoring of reactions occuring on organic surfaces, and 2) to develop static SIMS as a quantitative tool for determining the yields of surface modification reactions of biomedical importance. Toward this end, the relationship between the composition and microroughness of model organic surfaces and relative yields of molecular ions characteristic of the chemical structure of those surfaces is being studied. Current work is focused on static SIMS of model organic surfaces of patterned self-assembled monolayers (SAMs) formed by the adsorption of one or more (-functionalized n-alkane thiols on gold.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001296-16
Application #
6345041
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
16
Fiscal Year
2000
Total Cost
$12,271
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Tyler, Bonnie J; Peterson, Richard E (2013) Dead-time correction for time-of-flight secondary-ion mass spectral images: a critical issue in multivariate image analysis. Surf Interface Anal 45:475-478
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Medzihradszky, Katalin F (2005) Characterization of protein N-glycosylation. Methods Enzymol 405:116-38
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Wagner, Victoria E; Koberstein, Jeffrey T; Bryers, James D (2004) Protein and bacterial fouling characteristics of peptide and antibody decorated surfaces of PEG-poly(acrylic acid) co-polymers. Biomaterials 25:2247-63

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