We have developed protocols to assess the physiology of isoolated leukocytes and leukocytes in blood. These protocols involve the analysis of cell function and the expression of surface receptors indicative of cell activation. We have examined the expression of adhesive markers in trauma patients (Fry). We are beginning to characterize the response of leukocytes in septic neonates to administration of GM-CSF (Ohls) and the response of leukocytes in breast cancer patients to the administration of taxol and its carrier (Rogelj).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001315-14
Application #
5223195
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Frumkin, Jesse P; Patra, Biranchi N; Sevold, Anthony et al. (2016) The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation. Nucleic Acids Res 44:8073-85
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